Evaluation of the in vitro inhibitory effects of prumycin on the growth of Babesia and Theileria parasites

Document Type : Original Article

Author

Department of Parasitology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, El-Behera Egypt

Abstract

Prumycin is a carbohydrate antibiotic. It was isolated from a Streptomyces sp. at Kagawa Prefecture, Japan. It has antifungal, antitumor, and antimalarial activities. The inhibitory properties of prumycin were evaluated in vitro cultures of Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi; furthermore, the in vitro drug combination with clofazimine was assessed for Babesia bovis and Babesia caballi. The IC50 values of prumycin were 22.3, 0.96, 1.89, and 21.17 μM for B. bovis, B. bigemina, B. caballi, and T. equi. The combination of prumycin and clofazimine had a synergetic action on Babesia parasites that improved the potency and decrease the possible toxic side effect in B. caballi and B. bovis cultures. Therefore, prumycin might be of value in blended therapy of babesiosis and theileriosis and further studies are required to evaluate its in vivo effects.

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